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MATERIAL AND METHODS: and Bon nycllsle et a I (1962) observed an increase of the level or brain serotonin during anesthesia with clher and other central nervous ~y~tem depressants. Neff et al (1967) and Diaz et al (1968) found an increase of cerebral serotOnin level in animals during anaesthesia using different anaesthetics. Lida Swafford (1966) posllJlated a direct relationship between general anaeslhesia and Ihe level of serotonin in blood and she suggested that the u~c or antiseratonin agenl!> prophylactically during gentral anaesthesia might result I n red ucl ion of the incidence of such complications. In the present work we planned to subjl:ct experimental animals (rabbits) to four dif(erentlypcs of inhalation anaesthesia using. ether. halothane, trilene and chloroform and estimale the serotonin level in blood, brain. kidneys and small Illtcstinc during both 1he excitatory as well as the surgical stages of <Incslhcsia. We aimed 10 establish a relationship between Ihe serotoni n level and llle sta Ie of anaesthesia and to observe varialions between the different types of generi'll inhalCltion anaesthetics.

The Effect of General Anaesthesia on the Serotonin Levels in Brain, Blood, Kidney and Small Intestine of the Experimental Animals