Nobiletin, a polymethoxylated flavone from citrus peels, induces differentiation of normal human epidermal keratinocytes | Zendy

Kenji Ohguchi | Zendy; Munekazu Iinuma | Zendy; Yoshinori Nozawa | Zendy; Masafumi Ito | Zendy

Open Access

Nobiletin, a polymethoxylated flavone from citrus peels, induces differentiation of normal human epidermal keratinocytes

Author(s) -

Kenji Ohguchi,

Munekazu Iinuma,

Yoshinori Nozawa,

Masafumi Ito

Publication year - 2014

Publication title -

journal of medicinal plants research

Language(s) - English

Resource type - Journals

ISSN - 1996-0875

DOI - 10.5897/jmpr2014.5380

Subject(s) - nobiletin , chemistry , involucrin , keratinocyte , flavones , keratin , biochemistry , flavonoid , biology , in vitro , antioxidant , chromatography , paleontology

Nobiletin, a polymethoxylated flavone from citrus peels, is known to have a wide range of pharmacological activities. In this study, we examined the effects of nobiletin on differentiation of normal human epidermal keratinocytes (NHEKs). Treatment of NHEKs with nobiletin was found to cause marked increases in the expression level of keratin 10 (K10) and involucrin, differentiation makers of keratinocytes. Key words: Nobiletin, polymethoxylated flavone, citrus, keratinocyte, keratin.

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