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With the flourishing omics era, thousands of potential BMs have been identified and published, representing an increase of opportunities for improved diagnosis, develop more effective treatments and better cancer prognosis. Despite the auspicious omics, in 2011 it was estimated that more than 150 thousand manuscripts documenting equal or greater number of BMs, but to date less than 100 were validated in routine clinical practice [4]. Added to this, recently The Cancer Genome Atlas (TCGA) showed that a large battery of genomics and proteomics data did not improve the prognosis potential of clinical variables in patients with different types of cancer [5].

Opportunities for biomarkers with potential clinical use in oral cancer