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In this study, we examined the effects of organic types of calcium derived from oyster shell (OS-Ca) and nano-calcium(Nano-Ca) on the bio-availability and physiological responses associated with bone health in ovariectomised rats. Increasedbody weight, which is one of the physiological effects of ovary removal, was significantly recovered by Nano-Ca treatment(p<0.05). The reduced calcium level in the liver in ovariectomised rat was increased significantly with OS-Ca and Nano-Catreatment (p<0.05), suggesting improved calcium bio-availability. Alkaline phosphatase (ALP), osteocalcin, and deoxypy-ridinoline (DPD) were analysed as biochemical markers of bone metabolism and health in the presence or absence of OS-Ca and Nano-Ca. ALP, osteocalcin, and DPD levels increased following ovary removal and tended to decrease after treat-ment with Nano-Ca, indicating that Nano-Ca induces favourable bone metabolism. This result was reflected in the recoveryof bone mineral density (BMD) and bone mineral content (BMC) of the femur after Nano-Ca treatment following ovaryremoval. Taken together, our data show that the tested calcium treatments, especially using Nano-Ca, enhanced the bio-availability or absorption of calcium and positively affected bone metabolism in ovariectomised rats.Key words: ovariectomy, nano-calcium, calcium bioavailability, bone metabolism

Nano-Calcium Ameliorates Ovariectomy-Induced Bone Loss in Female Rats