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This study was conducted to examine the effects of low molecular weight gelatin hydrolysates (GH, less than 3kDa),extracted from pig skin collagen on the bone metabolism of ovariectomized (OVX) rats. The rats in the experimental groupswere randomly segregated into six different treatment groups such as 1) NC, the normal rat fed AIN 93 diet (basal diet) only;2) OC, the OVX rat fed the basal diet only; 3) GH 0.1, the OVX rat fed the basal diet with 0.1% GH; 4) GH 0.8, the OVX ratfed the basal diet with 0.8% GH; 5) G 0.1, the OVX rat fed the basal diet with 0.1% gelatin; 6) G 0.8, the OVX rat fed thebasal diet with 0.8% gelatin. Body weight gain in the GH 0.1, GH 0.8, and G 0.8 was significantly higher than those in theNC and OC. Feed intake of the GH 0.1 and GH 0.8 was higher than that of the NC and OC, while no significant differencewas found in feed efficiency ratio (FER). BMD of the GH 0.8 was higher than that of the OC. However, gelatin hydrolysatesand gelatin resulted in higher BMC level compare to the OC. Serum HDL-cholesterol of rat fed GH and gelatin was higherthan that of OC ( p<0.05). LDL-C of the GH 0.1 and the GH 0.8 tended to be less than that of OC. Serum alkaline phosphatase(ALP) of the GH 0.1 was lower than that of the OC. The serum of GH 0.8 showed lower osteocalcin value than the OC(p<0.05). In addition, GOT and GPT levels significantly decreased in all treatment groups. These results indicated that gelatinhydrolysates from pig skin gelatin hydrolysates enhanced BMD and serum biochemical parameters related to bone metabo-lism. Therefore, the gelatin hydrolysates could be used as a beneficial material to improve bone health. Key words: gelatin, collagen, osteoporosis, bone metabolism, pig skin

Effect of Pig Skin Gelatin Hydrolysates on the Bone Mineral Density of Ovariectomized Rats