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The value of combination anti-remodelling therapy for heart failure (HF) secondary to mitral regurgitation (MR) is unknown. We studied the effect of anti-remodelling therapy on clinical and echocardiographic parameters in patients with severe chronic rheumatic mitral regurgitation (CRMR) presenting in HF.

Is there a role for combination anti-remodelling therapy for heart failure secondary to chronic rheumatic mitral regurgitation?