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Spitz tumors are a heterogenous group of melanocytic neoplasms, which on histology demonstrate enlarged oval, epithelioid or spindled melanocytes, often in association with epidermal hyperplasia. The degree of pigmentation and presence or absence of maturation is variable. The moleculargenetic basis for these variations in histomorphology is increasingly being recognized. Spitz tumors typically harbor HRAS activating mutations, inactivation or deletion of BAP1 or gene fusions involving the kinases ROS1, ALK, NTRK1, BRAF, RET, MET or NTRK3 [1]. Some of these aberrations have been associated with progression to melanoma, while others have not [2]. There is little in the literature regarding the impact of particular molecular subtypes of Spitz on clinicaldermoscopic appearance. Most publications describe the clinical-dermoscopic features common to Spitz tumors as an entire category. We deduce that, as many of these neoplasms have characteristic histomorphology, clinical-dermoscopic features may be relatively consistent for a particular moleculargenetic aberration. Herein, we describe the clinicaldermoscopic features of a Spitz tumor with an LMNANTRK1 fusion presenting in an adult. Case Presentation

Dermoscopic Features of Spitz Tumor With LMNA-NTRK1 Fusion