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A 76-year-old Caucasian man came to our attention for lymphadenopathy of a 3-cm right inguinal lymph node (Figure 1A), subsequently diagnosed histopathologically as nodal melanoma metastasis. Upon total body skin examination, multiple suspicious lesions on the trunk and limbs showed dermoscopic evidence of regression. Four of the lesions met additional atypical dermoscopic criteria and were excised to rule out primary melanoma (Figure 1, B-D). The excised lesions were flat and located on the right lower limb, right abdomen, and right upper arm. The histopathological diagnosis of the right lower limb lesion (ipsilateral to the nodal metastasis) was a primary melanoma with Breslow thickness of 0.3 mm, no ulceration, wide regression (>75%), and fibrosis of the superficial dermis (Figure 2, A and B). The remaining 3 lesions were dysplastic nevi with regression and fibrosis (Figure 2, C and D). A total body CT scan showed brain, adrenal, lymphatic, and bone metastases. As the nodal metastasis proved BRAF (V600K, V600R, V600M) positive, combined target therSpontaneous Regression of Primary Melanoma and Multiple Melanocytic Nevi in a Patient With Metastatic Melanoma