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Melanocytes may assume a variety of shapes: epithelioid, round, spindled, pagetoid, dendritic, and with clear cytoplasm, among others. A type of melanocyte with multivacuolated cytoplasm surrounding a dark-stained scalloped nucleus was initially described by Eftychiadis et al as “sebocyte-like” [1]. These melanocytes are more commonly seen in benign congenital nevi, but also have been rarely reported in malignant melanoma, with only a few case reports in the literature [2]. The clear cell change is believed to result from intracellular enlargement of melanosomes with separation of their fibers. Such neoplasms may mimic sebaceous neoplasms and clear cell carcinoma. We report a case of a metastatic melanoma with undifferentiated cells exhibiting sebaceous-like features. Case Presentation

Metastatic melanoma with sebocyte-like melanocytes and widespread visceral involvement