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Amyloidosis represents a group of diseases characterized by extracellular deposition of amyloid and is traditionally classified as systemic or localized. Primary localized cutaneous nodular amyloidosis (PLCNA) is the rarest form of cutaneous amyloidosis, usually occurring equally among genders. It manifests as single or multiple nodules or infiltrated plaques, usually localized on the face, particularly the nose, genitals, trunk, and limbs. Progression to systemic involvement is quite uncommon, occurring in approximately 7% of cases [1].

Primary Localized Cutaneous Nodular Amyloidosis on a Toe: Clinical Presentation, Histopathology and Dermatoscopy Findings