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Extracellular matrix (ECM) is a major component for the regulation of cell activity. The different modules of the proteins which constitute the extracellular matrix macromolecules represent for the cells which enter in contact with them, new signals capable of activating several intracellular signaling pathways, resulting in the modulation of numerous cell functions. Tissue engineering tries to develop new materials based on these components as scaffolds for cells to promote their adhesion and growth. In this work, genetic engineering techniques were used to design and biosynthesize an extracellular matrix analogue based in the elastin component. The structural base of our scaffold is an elastin –derived sequence which confers an adequate mechanical behavior. In addition, several domains were included, for adding new bioactivities to this elastin-like polymer (ELP). Some of these elastic domains were modified to contain lysine for cross linking purposes. The polymer also contained periodically spaced fibronectin CS5 domain enclosing the well known cell attachment sequence REDV. Finally, the polymer had target sequences for proteolitic action.

Obtención de un polímero de tipo Elastina modificado con secuencias Bioactivas y Biodegradables, para su aplicación en ingeniería