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Background:  Integrons are the major reasons of multidrug resistance (MDR) among enteropathogenic bacteria. Occurrence of horizontal gene transfer between integron-carrying microorganisms and other enteric bacteria may increase the rate of emergence of integron-associated antibiotic resistance.    Objectives:  The objective of this study was to investigate class 1 integrons among members of enteropathogenic bacteria isolated from patients in Iran.    Materials and Methods:  A total of 120 enteropathogenic bacterial isolates from diarrhoeal patients were included in this study. Identities of the isolates were investigated by biochemical tests and confirmed by genus or species specific PCRs. Antimicrobial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Presence of class 1 integron among the isolates was investigated using primers specific for the integrase gene conserved region.    Results:  The result of this study showed the highest resistance to trimethoprim and cotrimoxazole, especially in enteropathogenic  Escherichia coli  (EPEC) (100%),  Shigella sonnei  (93.7%) and  Vibrio cholerae  (95%). The results showed that 16 (57.1%) of the 28 EPEC, 9 (25%) of the 36  Salmonella enterica , 32 of the 13 (40.6%)  Sh. sonnei , and only 1 (4.2%) of the 24  V. cholerae  isolate harbored class 1 integron.    Conclusions:  The data obtained in the present study suggested that class 1 integrons are widely distributed among members of  Enterobacteriaceae . The resistance patterns of our  E. coli ,  S. sonnei , and  S. enterica  isolates were nearly identical, suggesting the same genetic elements involved in attainment of multi-drug resistance.

Genetic Elements Associated With Antimicrobial Resistance Among Intestinal Bacteria