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Our findings support the role of NMDARs in pregabalin antinociception, because the NMDAR agonist, unlike the antagonist, decreased the antinociceptive effect of pregabalin, even if tail flick is not an adequate pain assessment method in this regard.

The Role of NMDARs Ligands on Antinociceptive Effects of Pregabalin in the Tail Flick Test