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The possibility of acute hepatotoxicity caused by dimethylformamide (DMF) requires regular monitoringof the workers who are using DMF to prevent the occupational disease. The authors performed ambient andbiological monitoring of workers involved in synthetic leather manufacturing processes using DMF to assess thecorrelation between the markers of ambient and biological monitoring of DMF. The authors monitored 142 workersoccupationally exposed to DMF from 19 workshops in the synthetic leather and ink manufacturing industries locatedin northern region of Gyeonggi-do. The subjects answered questionnaire on work procedure and use of personalprotective equipment to be classified by exposure type. DMF in air samples collected using personal air samplers,diffusive and active sampler, was analysed using gas chromatograph-flame ionization detector (GC-FID) with DB-FFAP column (length 30 m, i.d. 0.25 mm, film thickness 0.25 µm). Urinary N-methylformamide (NMF) wasanalysed using gas chromatograph-mass selective detector (GC-MSD) at selected ion monitoring (SIM) mode withDB-624 column (length 60 m, i.d. 0.25 mm, film thickness 1.40 µm). Geometric mean (GM) and geometric standarddeviation (GSD) of the ambient DMF was 6.85 ± 3.43 ppm, and GM and GSD of urinary NMF was 42.3 ± 2.7mg/L. The ratio of subjects with DMF level over 10 ppm was 44%, and those with urinary NMF over 15 mg/L was 87%. NMF in urine adjusted by DMF in air was 4.61 ± 2.57 mg/L/ppm and 9.50 ± 2.41 mg/L/ppm,respectively, with or without respirator. There was seasonal differences of NMF in urine adjusted by DMF in air,7.63 ± 2.74 mg/L/ppm in summer and 4.53 ± 2.29 mg/L/ppm in winter. The urinary NMF concentration whichcorresponds to 10 ppm of ambient DMF was 52.7 mg/L (r=0.650, n=128). Considering the difference of the routeof exposure which resulted from the compliance of wearing personal protective equipment, the estimatedcontribution of respiratory and dermal exposure route for DMF was 48.5% vs. 51.5%.Key words: Dimethylformamide (DMF), N-Methylformamide (NMF), biological monitoring, occupational expo-sure, dermal exposure, personal protective equipment

analytical science and technology/bunseog gwahag

Assessment of correlation between markers of ambient monitoring and biological monitoring of dimethylformamide for workers in synthetic leather manufacturing factories in Korea