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Objective: Lymphadenopathy may be the first symptomof many diseases. Enlarged lymph nodes may show significantregional differences in the etiologic profile. In thisstudy we investigated patients with peripheral lymphadenopathydiagnosed by excisional biopsy.Methods: A retrospective study was done of 67 lymphnode biopsy specimens obtained from adult patients andsubmitted for histopathological examination over a 5-yearperiod.Results: The average age of the patients was 37.9±15years, 29 (43.3%) were male. The regions of the lymphadenopathyexcised were axillary (n = 36, 53.7%), inguinal(n = 22, 32.8%), and cervical area (n = 9, 13.4%) respectively.About one-third (n=23; %34.3) of the patientshad malignancies. Malignancies were non-Hodgkin’s lymphoma(n=11, 16.4%), Hodgkin lymphoma (n= 7, 10.4%)and metastases (n = 5, 7.5%), respectively. Tuberculosislymphadenitis (n=20; %29.9) and non-specific lymphadenitis(n=19; %28.4) were the other common causes.Non-specific lymphadenitis included reactive hyperplasia,benign follicular hyperplasia, and mixed follicular hyperplasia.Lymphadenopathy diameter and the presence ofgeneralized lymphadenopathy were significantly higher inmalignant tumors.Conclusion: Although fine-needle aspiration biopsy maybe useful in the differentiation of benign and malignantlymphadenopathies, inability of the diagnosis is often encountered.In addition, an excisional biopsy is needed forthe diagnosis of lymphoma. Excisional biopsy is a diagnosticprocedure that can be applied safely with minimalmorbidity and mortality. On the other hand, especially inpatients with tuberculosis lymphadenopathy incisional biopsyis contraindicated as it can lead to sinus and fistulaformation.Key words: Lymphadenopathy, adults, excisional biops

Peripheral lymphadenopathy in adults: Results of 67 cases of excisional biopsy