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The clear cell sarcomas of soft tissue are rare tumors originating from neural crest cells and presenting with poor prognosis. By the reason of the resemblance of histological properties to malign melanoma (eg. the imsmunoreactivity to S100 and HMB45, the presence of meslanosomes ultrastructurally), these tumors are also desfined as malign melanomas of soft tissue. But distinctively from cutaneous melanoma, clear cell sarcoma is almost always deeply localized and the biological behaviour of the last one is also different. The differential diagnosis between clear cell sarcoma and desmoplastic or spindle cell malign melanoma may be more difficult because of the dermal localization of the last ones. In our case, it was observed an infiltrative tumor composed of uniform seeming cells with vesicular nuclei, distinct nucleoli, pale eosinophilic and sometimes clear, scant cytoplasms, in addition to necrotic areas. On immunohistochemical exsamination, the tumoral cells showed a positive immunoresactivity to vimentin, S100, HMB45, and SMA, while showsing negative immunoreactivity with CD34, PanCK, EMA, LCA, CD99 and desmin. Ki-67 proliferation index was destermined as approximately 50%. Because of deep localsization and different morphological-immunohistochemical findings of the tumor, the case was diagnosed as âclear cell sarcomaâ. It was observed a tumor with similar morsphology in the biopsy sample taken from vertebra of the patient one month later than the first material and this was commented as the metastasis of the tumor to vertebra.

A rare chest wall localized soft tissue sarcoma: Clear cell sarcoma