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Trichofolliculoma is a rare benign tumor originating from hair follicle tissue and typically occurring on the face. Clinically, the tumor consists of a small, dome-shaped nodule, commonly with a central pore and an immature wool-like tuft. Histological examination shows a cyst lined by squamous epithelium with associated follicular structures. The keratin-filled, epidermal-lined cyst is a “primary” hair follicle with numerous radiating “secondary” hair follicles. Here we report a case of trichofolliculoma of the upper lip. A 70-year-old woman was referred to our hospital because of swelling of the upper lip and oral vestibule. Computed tomography and magnetic resonance imaging showed an upper lip tumor. Clinical symptoms had been modified by a history of verruca vulgaris in the nasal cavity, thereby precluding diagnosis. We performed resection of the tumor as a dermoid cyst. The histopathological diagnosis was trichofolliculoma. No sign of recurrence has been detected since the treatment.

Trichofolliculoma with swelling of the upper lip and oral vestibule