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To examine the distribution of hyaluronic acid (HA) in murine temporomandibular jointsynovium, histochemical and immunohistochemical techniques were employed to study the synovial membrane, using hyaluronic acid binding protein (HABP), which specifically binds to HA, and antibodiesagainst CD44, serving as hyaluronan receptor.HABP reactivity was detected in synovial lining cells, collagen fibers, and capillaries. CD44 reactivitywas detected on the cell surface of all synovial lining cells. These results suggest that HA is distributed intemporomandibular synovial tissue and that CD44 expressed as hyaluronan receptor is involved in theregulation of HA.

Expression of hyaluronic acid binding protein (HABP) and CD44 in murine temporomandibular joint synovium.