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Cancers are considered to be formed by a multi-hit process of malignant transformation, which involves culmination of a number of aberrant genetic events. Comparative genomic hybridization (CGH), a recently developed molecular cytogenetic method, was used to study seven oral squamous cell carcinomas (SCCs) surgically resected at our department, and to analyze regions with DNA copy number abnormalities.DNA copy number increases were observed on chromosome 8 p in all cases. Five of seven cases had increased DNA copy numbers on chromosomes llq and 13q, and four cases had increased DNA copy numbers on chromosomes 1 q, 3 q, 5 p, llp, and 20p. Four cases had decreased copy numbers on chromosome 18q. Amplification of oncogenes and loss of tumor suppressor genes on these chromosomes was apparently related to the development of oral SCCs. As CGH provides a global analysis of chromosomal changes and rapidly identifies regions with DNA copy number changes, it may be useful in the diagnosis and prognosis of oral cancers if more CGH data are collected.

Detection of common regions with DNA copy number abnormalities in oral squamous cell carcinomas. Examination by comparative genomic hybridization.