English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Plasmodium vivax is the most geographically spread Plasmodium species, however in Africa, and P. falciparum is considered more prevalent in sub-Saharan Africa (sSA). Hence, most control strategies in sSA have been biasedly towards falciparum malaria. However, with more sensitive malaria diagnostic tools, there are reports of increasing occurrence of non-falciparum, especially P. vivax malaria in sSA. P. vivax is thought to be benign however, there are current reports of fatal cases recorded from infection with P. vivax single or mixed infection with falciparum. Besides, vivax malaria is capable of going into dormancy in the liver and recrudescence after several days, weeks, or months which makes it difficult to cure. Chloroquine is the drug of choice for and remains effective against P. vivax though, P. falciparum is resistant. ACTs are used for falciparum malaria chemotherapy in sSA and, it is plausible that ACT use could be favouring adaptive selection for P. vivax in the population. Therefore, it is important to understand the epidemiology, biological processes and host factors promoting the increase in vivax malaria on the continent. In this chapter, we discuss the mechanisms for invasion of red blood cells, trends in increasing prevalence of vivax malaria, diagnostic tools, and the public health implications of P. vivax and P. falciparum co-endemicity in Africa.

Increased Trends of P. vivax in Sub-Saharan Africa: What Does it Mean for Malaria Elimination?