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The world’s largest focus of opisthorchiasis caused by cat fluke Opisthorchis felineus Rivolta, 1884, is associated with the Ob-Irtysh basin (Russia). The chapter provides data on the history of discovery and the study of opisthorchiasis. Features of the morphology and life cycle of O. felineus are described. Data on the infection of intermediate hosts (mollusks and cyprinids fish) are provided. Species of fish that have important epizootological significance are indicated. The incidence of opisthorchiasis in the people of different age and social groups, clinical manifestations, pathogenesis, and complications is discussed. The climatic and social factors that contribute to maintaining the focus of opisthorchiasis are described. The measures of personal and social prevention of the people are given.

The World Largest Focus of the Opisthorchiasis in the Ob-Irtysh Basin, Russia, Caused by Opisthorchis felineus