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Ebola virus and the marburgviruses are distinct filoviruses that share common clinical presentations and clinical management protocols. However, the marburgviruses are not as well known as is their close relative, Ebola virus, and are a much less frequent cause of human outbreaks. Marburg virus disease (MVD) is caused by two marburgviruses that are clinically indistinguishable—Marburg virus and Ravn virus. There is scant information available concerning MVD in pregnancy, but it appears clear that, similar to Ebola virus, MVD infection is associated with an extremely high maternal and fetal mortality rate. This chapter will examine what is known about Marburg and Ravn virus infections in pregnant women, their clinical outcomes, and the pathogenesis of MVD in experimental animal models of infection. These data will be compared with the more comprehensive information available regarding Ebola virus disease in pregnancy including its effects on pregnant women and the fetus.

Maternal Filovirus Infection and Death from Marburg and Ravn Viruses: Highly Lethal to Pregnant Women and Their Fetuses Similar to Ebola Virus