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Probiotics (also called psychobiotics or bio-friendly agents) defined “as a source of live (viable) naturally occurring microorganisms (direct-fed microbials, DFMs)” have been used as dietary supplements to target gut microbiota (microbiome) for a novel promising therapeutic approach of various diseases including social stress-induced mental disorders in humans and various experimental animals. In this study, chickens were used as an animal model to assess if dietary supplementation of probiotic, Bacillus subtilis, reduces aggressive behaviors following social challenge. These results indicate dietary supplementation of the Bacillus subtilis based probiotic reduces aggression in chickens. These results suggest dietary probiotics could be a suitable strategy for increasing hosts’ health status and well-being.

Gut-Brain Axis: Probiotic, Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System