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Oxidative stress (OS) is implicated as a unifying factor between chronic kidney diseases (CKD). We compare the oxidants and antioxidants state in patients with PD according to DM status. An analytical cross-sectional study was performed. LPO, 8-IP and ON were determined as oxidants, and SOD and total antioxidant capacity (TAC) as antioxidants in patients on PD with DM and No-DM. 77 patients were included, 35 with DM and 42 No-DM patients. DM patients were older (p<0.0001), had higher Body Mass Index (p<0.0001), significant increase in glucose (p<0.0001) and more hypertension (p<0.0001). The levels of LPO were found significant increase in DM patients, and No-DM patients vs. the healthy controls (HC) (p<0.0001). The levels of 8-IP in DM and No-DM were found significant decreased vs. HC (p<0.0001). The levels of NO in HC were 197.97±34.20 μM and in DM and No-DM patients were significant decreased (p<0.0001). There was an increase in the activity of SOD in DM patients, and No-DM vs. HC (p<0.0001). Levels of TAC in HC were 2.62±0.17 mM, significantly decreased levels were found in DM and No-DM patients (p<0.0001). We found imbalance in the oxidative stress markers characterized by increased LPO products and decrease the antioxidant defense system. Notable decrease in NO levels favors secondary endothelial dysfunction

Increase of Oxidants and Antioxidant Consumption in Patients with Type 2 Diabetes Mellitus in Peritoneal Dialysis