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Alzheimer’s disease (AD), the most common form of dementia in the aged people, is a chronic and irreversible neurodegenerative disorder. Early prediction, intervention, and objective diagnosis are very critical in AD. In this chapter, we will introduce the current progress in the prediction and diagnosis of AD, including recent development in diagnostic criteria, genetic testing, neuroimaging techniques, and neurochemical assays. Focus will be on some new applied methods with more specific examples, that is, cerebrospinal fluid (CSF) and blood proteins and peptides, which might serve as biomarkers for the diagnosis of AD. We will also discuss biomarker-based diagnostic strategies and their practical application.

Precision Medicine: Role of Biomarkers in Early Prediction and Diagnosis of Alzheimer’s Disease