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Tourette syndrome (TS) is a neuropsychiatric disorder with childhood onset. The core symptoms are motor and vocal tics. The majority of patients also suffer from psychiatric comorbidities. The pathophysiology of TS is not clear, but changes in different neurotransmitter systems—in particular the dopaminergic system—have been confirmed. Since there is increasing evidence that cannabis-based medicine (CBM) is effective in the treatment of TS, an involvement of the endocannabinoid system in the pathophysiology of TS has been suggested. The purpose of this chapter is to present existing evidence suggesting a pathophysiological role of the endocannabinoid system in TS and to summarize available data on beneficial treatment effects of CBM in patients with TS.

Possible Role of the Endocannabinoid System in Tourette Syndrome