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Over the past few decades, transition metal complexes have attracted considerable attention in medicinal inorganic chemistry, especially as synthetic metallonucleases and metalbased anticancer drugs that are able to bind to DNA under physiological conditions. The use of metal-based drugs presents the most important strategy in the development of new anticancer and antimicrobial agents. Negative side effects during treatment (such as vomiting, resistance, nephrotoxicity, ototoxicity, neurotoxicity and cardiotoxicity) prompted researchers to design new classes of DNA and protein targeting metal-based anticancer agents with potential in vitro selectivity and less toxicity. Knowledge of mechanism of the interaction zinc(II) and copper (II) ions with biomolecules and other relevant ligands is essential for understanding the cellular biology of delivery complexes to DNA and proteins. Results obtained from investigations provide useful information for the future design of potential zincand copper-based anticancer drugs. Different mechanism of interactions with selected biomolecules compared to platinum-based drugs has been observed.

Mechanism of Interactions of Zinc(II) and Copper(II) Complexes with Small Biomolecules