English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Metastatic tumor blood perfusion and interstitial fluid transport based on 3D microvasculature response to inhibitory effect of angiostatin are investigated. 3D blood flow, interstitial fluid transport, and transvascular flow are described by the extended Poiseuille’s, Darcy’s, and Starling’s law, respectively. The simulation results demonstrate that angiostatin has the capacity to regulate and inhibit the formation of new blood vessels and has an obvious impact on the morphology, growth rate, and the branches of microvascular network inside and outside the metastatic tumor. Heterogeneous blood perfusion, widespread interstitial hypertension, and low convection within the metastatic tumor have obviously improved under the inhibitory effect of angiostatin, which suits well with the experimental observations. They can also result in more efficient drug delivery and penetration into the metastatic tumor. The simulation results may provide beneficial information and theoretical models for clinical research of antiangiogenic therapy strategies.

intech ebooks

3D Numerical Study of Metastatic Tumor Blood Perfusion and Interstitial Fluid Flow Based on Microvasculature Response to Inhibitory Effect of Angiostatin