English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

There are several similarities and differences in electrical excitability between zebrafish and human ventricles. Major ion currents generating ventricular action potentials are largely the same in human and zebrafish hearts with some exceptions. A large T-type calcium current is unique to the zebrafish ventricle (absent in human ventricle), and two potassium currents (I Ks and Ito) may be absent in zebrafish ventricular myocytes. However, there are substantial differences among alpha subunit isoforms of the ion channel families or subfamilies (e.g. zebrafish Kv11.2 vs. human Kv11.1; zebrafish Kir2.4 vs. human Kir2.1) between human and zebrafish hearts. Contraction of zebrafish ventricle is strongly dependent on extracellular calcium, while human ventricle relies heavily on calcium stores of the sarcoplasmic reticulum. These differences may affect the use of zebrafish as a model in drug screening and safety pharmacology.

Excitation and Excitation-Contraction Coupling of the Zebrafish Heart: Implications for the Zebrafish Model in Drug Screening