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Plasmonic nanostructures have attracted considerable interest in biomarker sensing with the goal of rapid diagnostics and personalized nanomedicine. Surface‐enhanced Raman scattering (SERS) is a versatile technique for the characterization of the plasmonic effect of the metallic nanostructures as well as a sensitive read‐out approach for biomarkers detection. In this contribution, we will give a review on the key optical properties of plasmonic nanostructures as SERS substrate for protein biomarkers detection. As a con‐ sequence, two approaches, label‐free and SERS labels will be discussed in details for pro‐ tein biomarkers sensing by using the plasmonic nanostructures as the substrate.

Plasmonic Nanostructures as Surface-Enhanced Raman Scattering (SERS) Substrate for Protein Biomarker Sensing