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Rheumatoid arthritis (RA) is a chronic, debilitating inflammatory condition characterized by joint degradation, permanent disability. Excessive production of reactive oxygen species (ROS) is implicated in RA pathogenesis, leading to oxidative stress, tissue damage. In recent years, nano-particles have emerged as promising carriers for ROS regulation therapies in RA treatment. This review explores the interplay between ROS, RA, emphasizing the importance of cell signaling pathways in ROS control. The potential of nano-particles as targeted drug delivery systems to scavenge excess ROS, restore redox equilibrium within affected cells is discussed. Preclinical studies using ROS-neutralizing nano-particles in RA animal models have shown significant reductions in joint inflammation, cartilage degradation. Clinical trials have further validated the safety, efficacy of nano-particle treatments in RA patients, leading to improved disease activity, joint function. The review highlights the benefits of nano-particle-based ROS control therapies, including improved drug solubility, prolonged drug delivery, reduced systemic side effects,, enhanced specificity for inflamed joints. However, further research is needed to fully understand the intricate mechanisms of ROS management in RA, optimize nano-particle production, delivery. Overall, nano-particle-based ROS control therapy holds great promise for revolutionizing RA treatment, improving the quality of life for affected individuals.

Regulating Reactive Oxygen Species in Rheumatoid Arthritis: Insights into Cell Signaling Pathways, Nano-Particles as Carriers