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Aptamers are single-stranded DNA or RNA that can mimic the functional properties of monoclonal antibodies. Aptamers have high affinity, specificity for their target molecules, which can make them a promising alternative to therapeutic antibodies or peptide ligands. However, many aptamer drug candidates in clinical development have been discontinued due to suboptimal metabolic stabilities, pharmacokinetics. To address these issues, chemical modification can be used to enhance the metabolic stability, prolong the half-life of aptamer candidates. The chapter reviewed published data regarding the metabolic stability, pharmacokinetics of aptamer drug candidates from preclinical, clinical studies. The benefits, possible shortcomings of current modification strategies used in these aptamers were briefly discussed.

The Modification Strategies for Enhancing the Metabolic Stabilities, Pharmacokinetics of Aptamer Drug Candidates