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An accurate diagnosis gives leeway to cost-effective treatments. However, many diseases continue to evolve, hence, their aetiology is sometimes missed due to the procedures used during diagnosis. Protein-related diseases which include proteopathies (proteinopathies) such as neurodegenerative diseases; protein-energy malnutrition such as Marasmus and Kwashiorkor; and hormonopathy which are related to the deficiency or hyper-production of normal or aberrant protein derived hormones, are reviewed in this work. The work aims to elucidate more on the diagnosis of these diseases which are associated with the structure and function of proteins viz-a-viz their deficiencies and hyper-production in man. Their pathogenesis and the principles underlying their diagnosis are further discussed, to optimize the management of these diseases among patients.

Protein Detection in Clinical Diagnosis and Management of Prevalent Neurodegenerative Diseases and Metabolic Disorders