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According to the current point of view described in the literature, the transcription fac‐ tor aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as hypoxia‐ inducible factor (HIF)‐1β, is constitutively expressed and not influenced by oxygen tension. However, a study published two decades ago provided early evidence regarding a hypoxia‐dependent ARNT upregulation. This finding was subsequently challenged and neglected. Until now, only a limited number of publications focus on the regulation of ARNT in hypoxia. Therefore, appropriate studies and the putative mechanism mediating this cellular attribute are discussed. The advantages of an elevated ARNT expression level in tumour cells are delineated. This chapter provides an overview of hypoxia‐inducible ARNT as an emerging concept in HIF biology.

Hypoxic Upregulation of ARNT (HIF-1β): A Cell-Specific Attribute with Clinical Implications