English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The HER2-targeted therapy have profoundly changed the outcomes of women with HER2-positive breast cancers. Trastuzumab and pertuzumab, HER2-targeting monoclonal antibodies, lapatinib and Neratinib, small molecule inhibitors of HER2 and the epidermal growth factor receptor, and ado-trastuzumab emtansine, a HER2-positive directed antibody drug conjugate, are approved for the treatment of HER2-positive breast cancer. Cardiac toxicity is a known adverse effects of trastuzumab, and other HER2-directed therapy. In most cases it manifests as mild and reversible left ventricle dysfunction. Nevertheless, symptomatic heart failure is not rare. The incidence and severity of cardiac dysfunction is greatest among women who received HER2-directed therapy in combination with anthracycline-based therapy. In addition, a borderline low normal left ventricle ejection fraction; prior treatment with antihypertensive medication; and older age are other risk factors for trastuzumab-related cardiac dysfunction. HER2 signaling plays an important role in modulating myocardial response to treatment-related injury. Management of trastuzumab and the other HER2 targeted treatment-related cardiac dysfunction has two key components: withdrawal of HER2-directed therapy and treatment of underlying cardiac dysfunction. A multidisciplinary approach is recommended for an optimal outcome. This chapter reviews cardiac toxicity of trastuzumab and other HER2-directed therapy including epidemiology and pathophysiology of cardiac dysfunction, cardiac monitoring, treatment and prevention.

Cardiac Toxicity of HER2-Directed Therapy in Women with Breast Cancer: Epidemiology, Etiology, Risk Factors, and Management