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Clinical vitrification evolved slowly, with interests and acceptance being commercially driven by the development of unique devices, safer solutions, and the misconception that ultra‐rapid cooling in an “open” system was a necessity to optimizing vitrification success. Furthermore, the dogma surrounding the importance of cooling rates has led to unsafe practices subject to excessive technical variation and risky modifications to create closed‐storage devices. The aim of this chapter is to highlight important quality control factors (e.g., ease of use, repeatability, reliability, labeling security, and cryostorage safety) into the selection process of which device/solution to use, inde‐ pendent of commercial manipulations. In addition, we provide clinical and experimen‐ tal evidence in support of warming rates being the most important factor determining vitrification survival. Lastly, we exhibit indisputable support that aseptic, closed vitrification systems, specifically microSecure vitrification (μS‐VTF), can achieve success with attention to quality control details often lacking in open vitrification devices.

Quality Control Factors Influencing the Successful and Reliable Implementation of Oocyte and Embryo Vitrification