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Adipose tissue (AT) is a very important endocrine and paracrine organ that regulates oth‐ er tissues and organs. Dysfunction of AT leads to a wide range of disorders like obesity, insulin resistance, diabetes mellitus, cardiac disorders, tumors and others. Adipose tissue macrophages (ATMs) are the key actors in AT remodeling and dysfunction. Their role in AT dysfunction is nowadays increasingly investigated, but still their interplay and molec‐ ular mechanisms of actions have not been fully elucidated. In this chapter, we summar‐ ized the current knowledge about the role of macrophages in AT remodeling, dysfunction and related disorders and indicate the potential directions for future re‐ search.

Macrophages – The Key Actors in Adipose Tissue Remodeling and Dysfunction