English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Microgravity in life sciences is an important field of study, not only because of our interest in exploring and living in space for extended periods, but also for the potential insights it gives on earthbound health problems. With genome-wide array technologies, the study of micro‐ gravity effects on living organisms can be examined in much greater detail at the cellular and molecular levels which is key to elucidating the molecular mechanisms of this environmental factor. Microgravity is a main environmental risk factor of spaceflight [1, 2] and the adverse effects of microgravity have much in common with earthbound health problems related to low physical activity or reduced mechanical loading. Bone loss and muscle atrophy as well as immune system dysfunction are some of the main consequences common to both extended spaceflight and physical inactivity such as that associated with premature aging and degen‐ erative disorders [3, 4]. Remarkable similarities have been noted between the clinical presen‐ tation of spinal cord injury and prolonged gravity unloading including atrophy in muscle and bone, cardiovascular disturbances, and alterations in renal, immune and sensory motor [5]. Microgravity research also holds promise in the area of tissue engineering. Microgravity simulation devices such as Rotating Wall Vessel (RWV) have been increasingly explored to generate 3-D organ mimics for liver and pancreatic islet transplantations [6-9]. Continued effort in microgravity research will deepen our understanding of space adaptation response and improve our ability to treat health-related problems, such as spinal cord injury, diabetes, osteoporosis, and premature aging. A better understanding of microgravity effects at the molecular level could help in the development of countermeasures that will protect astronauts from the deleterious effects of living in space as well as lead to the development of treatments for human diseases here on Earth.

Identification of Putative Major Space Genes Using Genome-Wide Literature Data