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The synaptosome is the presynaptic part of the nerve ending with, as a rulе, a postsynaptic membrane in the region of the junction of the preand postsynaptic membranes that remains with the presynapse during homogenization and centrifugation. The presynaptic part of the synaptosome is a membrane-bound structure with a preserved cytoplasm (synaptoplasm), synaptic vesicles, mitochondria and some other cellular components. The term synaptosome was adopted by V.P. Whittaker and coworkers [1]. Together, V.P. Whittaker and C.O. Hebb first isolated and identified nerve endings in nervous tissue [2].

Synaptic Soluble and Membrane-Bound Choline Acetyltransferase as a Marker of Cholinergic Function In Vitro and In Vivo