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Cellulose, a natural polymer, has been widely used in blood purification due to its good biocompatibility, and excellent processing which can be easily formulated into beads, membranes and hollow fibers. Sorbent-perfusion is a novel approach of blood purification which can specifically remove endogenous and exogenous pathogenic toxins from the blood of patients [1]. The technique involves passing whole blood or plasma of the patient through a cartridge filled with an adsorbent which can easily adsorb the toxin molecules, see Figure 1 a,b. According to selectivity, generally adsorbents can be classified as broad spectrum, affinity adsorbents and immuno-adsorbents, of which the latter has the highest selectivity [2-5]. Materials, most commonly used are activated charcoal [6], porous resins and fibers. The pathogenic substances in the blood of patients are adsorbed by the adsorbent via hydrophilic (electro-static forces) or hydrophobic interactions. Macroporous resins usually show high adsorption capacities especially for the removal of high molecular weight or “middle molecules” toxins [7-9].

Bioactive Bead Type Cellulosic Adsorbent for Blood Purification