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Neuroblastoma (NB) is the most common extra-cranial tumor of childhood with more than 600 new cases per year in the United States. The clinical presentation is heterogeneous and dependent on age at diagnosis, staging, histology, and alterations such as MYCN amplification and chromosome 1p loss or 17q gain. High-risk patients with evidence of metastases have an overall survival rate of less than 40% despite intensive multimodality treatment. This high‐ lights the urgent need for new therapeutic intervention strategies. However due to NB characteristic molecular features, in about 10% of patients with metastases, tumors disappear by apoptosis [1].

Analysis of Apoptotic and Autophagic Pathways in Neuroblastoma by Treatment with Copper Compounds