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The Age of Enlightenment is the period in time when the method of reasoning known as the Scientific Method was developed. This revolution in science began with the description of the sun as the center of our solar system rather than the earth. Natural phenomena previously explained by spiritualists were now described by science. Given our still evolving under‐ standing of influenza, it is perhaps no coincidence that we describe the combined effects of the influenza virus gene segments with the word ‘constellation’, which has astrological roots describing the position of the stars. Interestingly, the name influenza also has astrological roots: it was borrowed from the Italian word influenza in the mid-17th century which, in turn, was derived from the Medieval Latin word influentia, a 14th century term that refers to the influence of the stars. The scientific rational to describe the influence of the influenza gene constellation on virus phenotype is currently being resolved. Here we try to shine some light on the subject by providing the reader with background information, recent experimental results and provide a framework for questions that remain unanswered.

Gene Constellation of Influenza Vaccine Seed Viruses