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Short chains fatty (SCFAs) acids are organic fatty acids that are the major products of bacterial fermentation of undigested dietary fiber and resistant starch in the colon. Propionate, acetate and butyrate are the main SCFAs produced from fermentation and serve as fuel for colono‐ cytes. SCFAs serve as regulators of intracellular pH, cell volume, and other functions associ‐ ated with ion transport. Moreover, SCFAs act as regulators of proliferation, differentiation and gene expression. Our recent studies reported that SCFAs promote autophagy in colon cancer cells. In this chapter, the regulation of autophagy by short chain fatty acids in colon cancer cells will be discussed in details including the mechanism of action.

Regulation of Autophagy by Short Chain Fatty Acids in Colon Cancer Cells