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Hypothalamus-derived dopamine and thyrotrophin-releasing hormone (TRH) have long been considered the main sources of prolactin (PRL) regulators in the anterior pituitary, whereas other substances also modulate PRL expression and secretion (Borrelli et al., 1992; Cai et al., 1999; Spuch et al., 2006). Recently, Vlotides for the first time observed that recombinant Nrg1 can control PRL secretion from rat RPL and growth hormone (GH) secreting lactosomatotroph GH3 cells, suggesting the emerging role of Nrg1 as a PRL regulator (Vlotides et al., 2009).

Neuregulin-1 (Nrg1): An Emerging Regulator of Prolactin (PRL) Secretion