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Simian malaria parasites were first reported in Malayan monkeys by Daniels in 1908 [1]. It had been assumed for a long time that transmission of simian malaria to humans would not be possible. However, an accidental infection of scientists in Atlanta, USA by mosquito bites in the laboratory proved that a simian malaria species– Plasmodium cynomolgi can be transmitted to humans [2, 3]. In 1965 the first natural infection in human was reported in an American surveyor who was infected in the jungles of Pahang, Malaysia [4]. Fortunately he returned to USA and was detected first as Plasmodium falciparum and later revised to Plasmodium malariae due to the band form of the parasite. Further examination proved that it was actually Plasmo‐ dium knowlesi [4].

Simian Malaria Parasites: Special Emphasis on Plasmodium knowlesi and Their Anopheles Vectors in Southeast Asia