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Given the rapid ageing of the population worldwide, global estimates of AD generally con‐ sidered to be the commonest subtype of dementia are expected to increase from the current estimated 25 million to 63 million in 2030, and by 2050, a staggering 114 million [1]. Over the last two decades in particular, significant but modest breakthroughs in pharmacological treatment of this devastating condition have occurred. Presently, there is increasing convic‐ tion that intervention (especially disease-modifying therapy) will have to be instituted at the earliest possible stage of the illness to confer the greatest benefit.

Predicting Cognitive Decline in Alzheimer’s Disease (AD): The Role of Clinical, Cognitive Characteristics and Biomarkers