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[Background] Segmental left ventricular (LV) wall systolic dysfunction has been considered a significant sign of coronary artery disease (CAD) for many years. However, it is well known that many heart diseases besides CAD cause abnormal LV wall motion. Therefore, it is essential to verify that segmental LV wall systolic dysfunction is due to myocardial ische‐ mia. Although coronary angiography is typically used to determine the clinical significance of CAD, it is also possible to visualize areas of ischemic myocardium noninvasively by echo‐ cardiography using microbubble contrast agents. Perfluorobutane microbubbles, consisting of a hydrogenated egg-phosphatidylserine shell encapsulating perfluorobutane gas, offers the advantage of resistance to destruction by ultrasound, thus enabling repeated scans per injection.

intech ebooks

A Noninvasive Alternative to Coronary Angiography: Myocardial Contrast Echocardiography Following Strain Map as a Gate Way to Myocardial Contrast Echocardiography Map