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Thanks to their low cost and their broad spectrum of activity in preventing or treating bacterial infections, sulfonamides (SAs) are one of the oldest groups of veterinary chemo‐ therapeutics, having been used for more than fifty years. To a lesser extent they are also applied in human medicine. After tetracyclines, they are the most commonly consumed veterinary antibiotics in the European Union. As these compounds are not completely metabolized, a high proportion of them are excreted unchanged in feces and urine. Therefore, both the unmetabolized antibiotics as well as their metabolites are released either directly to the environment in aquacultures and by grazing animals or indirectly during the application of manure or slurry [1-3].

What Do We Know About the Chronic and Mixture Toxicity of the Residues of Sulfonamides in the Environment?