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The high rate of disability and mortality among patients with Diabetes Mellitus (DM) is mainly caused by cardiovascular disorders. The pathogenic effect of a number of specific factors (hyperglycemia, hyperinsulinemia, insulin resistance) accelerates the development and progression of the diseases connected with atherosclerosis. They are the main causes of death among population of industrialized countries. The incidence of cardiovascular disease is 3-4 times higher among patients with Type II DM in comparison with patients having normal carbohydrate metabolism. However, atypical clinical course of coronary heart disease makes diagnosis of coronary insufficiency among patients with DM rather difficult. It results in later detection of disease, i.e. the disease is often detected on the stage of severe complications such as sudden death or circulatory failure [1]. According to Thomas Killip [2], asymptomatic myocardial ischemia occurs 2-4 times more often in diabetes, while Cohn P.F. and Fox K.M. [3] say about 5-fold increased risk of cardiac mortality among patients with asymptomatic myocardial ischemia. It should be noted that the presence of silent myocardial ischemia increases the risk of complications such as acute myocardial infarction and unstable angina [4].

Significance of Arterial Endothelial Dysfunction and Possibilities of Its Correction in Silent Myocardial Ischemia and Diabetes Mellitus