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Melanocytes are special pigment cells that reside predominantly in the skin and eyes. In the skin, melanocytes are located in the bottom layer (the stratum basale) of the skin's epidermis and in the hair follicles (Gray-Schopfer et al., 2001). Melanocytes produce melanins responsible for skin and hair color and perform protection function of the basal keratinocytes from ultraviolet light through synthesis and donation of melanin (Gray-Schopfer et al., 2001). Melanocytes maintain constant contact with the basal layer of the epidermis through direct interaction with basal keratinocytes and via secretion of soluble factors. Upon ultraviolet radiation, keratinocytes produce factors that control melanocyte proliferation, differentiation and motility (Gray-Schopfer et al., 2007). Melanocytes maintain during a lifetime a stable-ratio of 1:5 with basal keratinocytes (Fitzpatrick et al., 1979).

T-Cadherin Stimulates Melanoma Cell Proliferation and Mesenchymal Stromal Cell Recruitment, but Inhibits Angiogenesis in a Mouse Melanoma Model